..The "worst case" comment - couldnt agree more. However, in cases where cold-chain newbies with high value product wish to simulate temperatures of a shipping route directly through the Sahara with a layover on a tarmac in Tibet, it sure can be difficult to convince them otherwise! There once was a (large) company who wanted to qualify with a 2-8°C criteria using a "profile" of constant 50°C for 120 hours. Seriously. p.s. good luck with those Cubs.